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Author: marsuculix One star, 50 posts Add to my Favorite Fools Ignore this person (you won't see their posts anymore) Number: of 659  
Subject: #3 from ESMO: Cabo in CRPC patients Date: 9/30/2012 9:55 AM
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hi fellow Fools,

here are the data of the CRPC trial reported @ ESMO 2012 - already posted on

My take:
1) the study design was a non-randomized expansion of a phase 2 randomized discontinuation study - this means that all patients were already treated with Cabo and had no severe tolerability issues.
2) Encouraging: the dose of 40 mg seems to be as effective as 100 mg once daily.
3) Outstanding effect: 67% (26 of 39 pats.) showed a >=30% decrease in their circulating tumor cells - but why only 39 patients out of the initially 51 enrolled ? I have to dig deeper into the published data to answer this discrepancy.

So far no negative news for Cabo - IMO, nothing that could make EXEL shares plummet ahead of a probable MTC approval (in 2 to 3 weeks ?).

fool on,
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