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Subject:  cholesterol act two Date:  1/21/2005  11:58 AM
Author:  emiller8988 Number:  35779 of 46905

Well, we've met the three stooges LDL delivery truck. LDL levels are a critical risk factor for CV disease and the lower it goes (the more we get those idiots off the road) the lower CV risk goes. Little children have LDL levels in the 20-30 range. So far so good. Rising HDL levels are associated with decreasing risk... go get 'em Dudly Do-Right!

BUT! back to Framingham and those poor poor pin-cushion people. Over 1/3 of all heart attacks and strokes occur in apparently healthy folks with completely normal cholesterol levels. Enter rust! oxidation!... come hither inflammation. You see, when the little giblet of cholesterol gets dropped (so to speak) remember it tries to bury itself in the wall of the blood vessel. That process creates inflammation. It's the combination of cholesterol AND inflammation that cause trouble.

There are a number of molecular markers of inflammation that sit at the critical interface between the blood flow and the vascular endothelial cells. Those endothelial cells are a very active organ, intensely involved in the management of the disease. They're involved in the transmission of the cell adhesion molecules across that border. They're critically involved in the tethering and adhesion of the monocytes and the macrophages; attachment through the v