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Any good calculations/rules for selling large cap stocks?

I know the "sell when there's somewhere better to put your money" idea is best. And I've heard of setting your own earnings/losses targets. And I know how to analyze income stmts & balance sheets.

But I like having the Fool Ratio for small & mid cap, and wondered if someone's come up with a good ratio(s) or calculation(s) for large cap stock prices.

E.g., at what point are great stocks like MSFT, INTC, YHOO(?) overvalued or undervalued? Any books/websites out there that can help.

Own them because they are in the top 5 of a Keystone or Spark list (see the Foolish Workshop) and sell them if they are no longer in the top 5 of the list after a year and a day.
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