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PRECEDENT trial (P2):

PFS in FR+ (1-99% folate receptor+):
EC145 / doxil: 5.0 months
doxil alone: 2.7 months

PFS on FR++ (100% folate receptor+):
EC145 / doxil: 5.5 months
doxil alone: 1.5 months

ADRs are increased, but probably not high enough to get it rejected, the data are just too good i think.

P3 PROCEED trial results due 2013.

22,000 ovarian cancer patients, about half become platinum resistant. 10k x 85,000 is 850m. potential blockbuster here...
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