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Author: projectchris Big red star, 1000 posts Old School Fool Global Fool Add to my Favorite Fools Ignore this person (you won't see their posts anymore) Number: of 636  
Subject: Re: Exel-video explains PSA phenomenon Date: 2/4/2013 1:39 AM
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Exel-video explains PSA phenomenon or not. Early listening to video had me prematurely thinking that they might explain this phenomenon better.

Thought the video was interesting in that

Cabo treated mice were well tolerated up to 4 weeks, after that mice didn't look healthy. Thought to be that the mice didn't eat, and had translucent teeth. They did another study lowering dose over time, and mice were healthier.


Cabo demonstrated half of bone necrotic tumor cell death in models. Couldn't explain the other half not dying. Less tumor bone growth

Cabo demonstrated more bone growth in healthy bone. Went on to state this may be helpful to combine Cabo in Androgen deprivation treated patients as these patients go on to develop osteoporosis.

It is getting late, so I will put out some other interesting tidbits another day.
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