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Of course there is more to my investment thesis than just science.

I do not doubt this!

I look for companies that I think can reasonably go up 5 times with protection on the downside.

I am also looking for big winners (isn't everyone?).

But my intuition says to have a good sized position as I think I'm going to need several vacation homes

Need them? Really, what for?

Check Remi Barbier's holdings

I tend not to put too much emphasis on insider holdings. Especially with execs, they can have huge egos... it will lead them to do the most nonsensical things with money. Sometimes their behavior is well-founded, other times not. It's a data point, I agree.

There's a wimp out strategy also out there

Well, I do not hold PTIE. When I first found out about them (one of your posts), the price was at around $6 or so, and in the past year it was down to $2... I can rarely bring myself to buy stock that has risen so much in the past year (this is one of the problems that I had with SKYT as well, but I took a chance and it paid off). My instinct is to look for something that's currently beaten down, and PTIE does not look beaten down at the moment - I think I missed that ride. I have to put some trust in my methods and instincts, as they have worked pretty well for me so far. But it's interesting to look at from a purely hypothetical view. I would like to get a better feel for pharma and biotech, both areas of interest with potentially huge rewards.

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