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Author: Santa22 Old School Fool Add to my Favorite Fools Ignore this person (you won't see their posts anymore) Number: of 24974  
Subject: Re: Q's Re:Electrospray Mass Spectroscopy wins N Date: 10/10/2002 1:54 AM
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Hi genomeinvestor,
yout are a little bit late for that. Everybody is already using electrospray. You can get a standard LC-MS (electrospray coupled to chromatography) for under $200.000.-. The instrument I did my Ph.D. on was a prototyp from 1990 and did cost $2 millions with university discount (you get the point).
<I am wondering what your thoughts are on which current biotech companies are most poised to benefit from this novel technique.>

I pretty sure there are hardly any biotechs left who don't have one.

<As far as I know, ABI is one of the leaders of mass spec. in the Biotech realm.>

Biggest mass spec manufacturers are(no specific order):

Sciex/Perkin-Elmer/ABI
Bruker Daltonics, especially the big FT-ICR MS for a couple of $millions each
Finigan/Thermoquest
Agilent (former HP)
??? Too tired, can't think of any others right now.

Electrospray is just the technique to create the ions. You can then analyze them in different ways: Quadrupole/Time-of-Flight/Ion Cyclotron Resonance Fourier Transform (what a name :-))))
And it is important for biomolecules (proteins/DNA) because you can analyze very large molecules by mass without breaking them apart.
If you want to invest in a new analytical techniques that will probably change the way we analyze biomolecules look into LC-NMR. That's the future (Varian and Bruker). And NMR got the 50% of the Nobel prize, Fenn only 25% :-)

Santa


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