Hi genomeinvestor,yout are a little bit late for that. Everybody is already using electrospray. You can get a standard LC-MS (electrospray coupled to chromatography) for under $200.000.-. The instrument I did my Ph.D. on was a prototyp from 1990 and did cost $2 millions with university discount (you get the point).<I am wondering what your thoughts are on which current biotech companies are most poised to benefit from this novel technique.>I pretty sure there are hardly any biotechs left who don't have one.<As far as I know, ABI is one of the leaders of mass spec. in the Biotech realm.> Biggest mass spec manufacturers are(no specific order):Sciex/Perkin-Elmer/ABIBruker Daltonics, especially the big FT-ICR MS for a couple of $millions eachFinigan/ThermoquestAgilent (former HP)??? Too tired, can't think of any others right now.Electrospray is just the technique to create the ions. You can then analyze them in different ways: Quadrupole/Time-of-Flight/Ion Cyclotron Resonance Fourier Transform (what a name :-))))And it is important for biomolecules (proteins/DNA) because you can analyze very large molecules by mass without breaking them apart.If you want to invest in a new analytical techniques that will probably change the way we analyze biomolecules look into LC-NMR. That's the future (Varian and Bruker). And NMR got the 50% of the Nobel prize, Fenn only 25% :-)Santa
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