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Author: FatSam Add to my Favorite Fools Ignore this person (you won't see their posts anymore) Number: of 1856  
Subject: Re: Peptide mimetics and small molecule drugs Date: 5/12/2000 8:39 AM
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I'm with Digger65

There are lots of cases where a small molecule can't replace a protein. For example, the mechanism of action of monoclonal antibodies which are having a big surge of late (e.g. MLNM's Campath or BGEN's hepatitis B vaccine)couldn't be replaced by a small molecule (as far as I can imagine).

I would also add that the "ultimate goal" (as described by beachbum10) should include the stipulation of an orally available small molecule. Finding a peptide mimetic is a challenge in and of itself but making one that is orally bioavailable is an additional major challenge. However, therein lies the profit advantage over a protein therapeutic. Orally available drugs are in general: cheaper to make and much preferred by patients.

Good Board

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