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Drug development is a minefield. From the list of the 100 most promising drugs under development, I suppose the following might just as well be taken away.

Abgenix recently announced that further development has been discontinued.

Avan has discontinued development after some disappointments.

BMS has said they have not been able to show any benefit (compared to similar drugs).

Neotherapeutics has just reported the drug does not seem to provide any benefit for patients with Alzheimer's disease.

CA4P (Combrestatin).
The drug has been returned to Oxigene by BMS.

CLTX and GSK have problems with FDA for this one.

Ribozyme has been forced to stop the development of this drug as a monotherapy after disappointng results.

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