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Ken, I'm not knowledgable about the companies you mentioned,but, below is a quote from Ariads' front page:

ARIAD Pharmaceuticals is a leader in the discovery and development of proprietary platform technologies and small-molecule therapeutic products based on gene regulation and signal transduction. These enabling technologies distinguish the gene therapy and protein therapy products being developed by the Company and also may be licensed to pharmaceutical and biotechnology companies for use in their research and product development programs. ARIAD also is developing orally administered small-molecule drugs to inhibit signal transduction pathways that are critically involved in major diseases.

and next is a link to Company Press Releases:

One recent article on April 20, 2000 (in part):

ARIAD Pharmaceuticals, Inc. (Nasdaq: ARIA) today announced that the growth and differentiation of pluripotent stem cells -- cells that have the capability to turn into any cell type and tissue -- can be controlled using the ARIAD Regulated Gene Expression Technology (ARGENT(tm)) system. ARIAD and its collaborators at the University of Washington have overcome several of the major limitations to the development of stem cell therapy -- the inability to efficiently transfer genes into these rare cells, to control their growth, and to direct their differentiation towards the desired cell type and tissue.

Food for thoughts on Small Molecule
(disclaimer...long on Ariad, Geron & Celera)

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