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More power to you to gain enough mastery over the micro caps in medicine to make some money. I'm not sure I have the knowledge, or can gain enough, to invest the time to try. But I do think that we're probably reaching the end of the model which Big Pharma used to develop blockbusters. We need another model that can achieve blockbuster type returns for less investment -- kind of like moving from mainframes to minicomputers and then to PCs.

I think that, company size aside, it must be conceptually and organizationally difficult for a big pharma company to adopt a completely different model of drug research and development, plus the accordand marketing. I wouldn't be surprised over the next ten years, as patents expire and new patents are less lucrative, a number of these companies will disappear. It happened with computers. Or maybe there will be a few left, like GM and Ford, but constantly responding to the nimbler practices of the smaller, more innovative companies less bound to past success patterns that are no longer as successful.

As for PA, once can't help feel, and write, a little rabidly there at times -- after all, this election is not insignificant. My favorite moments are when someone with extremely opposite views lowers the loudspeaker and offers more measured and modulated arguments. Don't expect to get, or give many of those in the next three weeks, however. :-)
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