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More results released from the study that put hormone replacement therapy on its ear last year now indicate that it doesn't even work for the improved well-being for which it has been promoted.

What tends to get lost in the fine print is that these studies involve ONLY estradiol extracted from horse's urine, and a synthetic progesterone. Earlier studies have shown clearly that progestin has significant unpleasant side effects compared to prometrium, a progesterone that mimics what women produced naturally. Same with the difference between conjugated equine estrogen compared to estrace, for example. It isn't fair or objective to make sweeping statements about HRT in general unless/until compounds that mimic the human hormones both in their chemistry and a varied estrogen profile (estradiol + estriol + estrone).

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