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Author: applefoot Big red star, 1000 posts Old School Fool Add to my Favorite Fools Ignore this person (you won't see their posts anymore) Number: of 24974  
Subject: Quick Guide? Date: 5/19/2002 11:51 AM
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Quick guide to the top 100 drugs in current trials?

Well that's at least what this particular site believes.Mesoman gave us the trail for this piece on the Novogen board. (Mesoman BTW suffers from mesothelioma and is just about to start on the phenoxodiol Cleveland Clinic phase II trials). It is from a company called R&D Directions and it lists 100 of what it believes are the best drugs in current trials. We could all argue the composition of the top 100, no doubt, but I found the list very useful as a ready reference.

This is what they have to say on their picks...

There is no time to investigate medicines that offer marginal or no improvement over existing drugs. The brutal marketplace will only tolerate medicines that deliver the best value, those that represent true medical advances. The editors of R&D Directions have reviewed about 500 drugs in U.S. Phase I through Phase III clinical trials to determine which ones fit the bill. At least 100 have qualities that differentiate them from the rest.


http://216.239.37.100/search?q=cache:5hgO-KfaQi4C:www.pharmalive.com/directions_month/flash/2010.asp+panzem&hl=en&ie=UTF8

And this is what they have to say on phenoxodiol. Actually there is yet more been discovered on the action of phenoxodiol which involves the protein C-flip...... but that story is still unfolding and will be reported upon at the Novogen board when it is clearer.

THE UNIQUENESS: Phenoxodiol belongs to the new generation of anticancer drugs known as small-molecular signal transduction inhibitors that target abnormal signaling processes in cancer cells. Switching off these abnormal processes causes the cancer cells to stop growing and/or to die. Noncancer cells with normal signaling processes generally are not affected. Phenoxodiol is the first drug to be tested in humans that targets the signaling protein, sphingosine kinase. Studies have suggested that sphingosine kinase is a critically important protein in the function of normal cells and a vital signaling protein that needs to malfunction as part of the cancer process.

How many of your favourites are included and which ones that are missing would you include, I wonder?

Jon
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