Thanks for the answers. No grandbabies on this trip, just Grandma and her Minnie. I actually find that I can drive longer in the Winnebago than in my Honda. I start to feel tired in the Honda after a few hours, and I think that is because you get kind of "bored". Driving the motorhome, I find myself having to stay alert and concentrated on driving. When your vehicle is 8 1/2 feet wide, you don't have the drift room that you have in a car.
I appreciate the thoughts though, and if anyone else has any input, please let me know.
P.S. The trip is roughly 1,300 miles. I think that 3 days would be a pretty easy pace. Perhaps the full night's sleep is a good idea. I'm really not in a real hurry, except for the desire to get to the warmth!