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Author: sheila727 Big gold star, 5000 posts Old School Fool Add to my Favorite Fools Ignore this person (you won't see their posts anymore) Number: of 24974  
Subject: Re: URL for Adaptive Date: 7/9/2013 11:22 AM
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This company does not inspire my confidence, because they distort reality in their attempt to boost the importance of their relatively narrow focus.

My suspicions were raised at the get-go, looking at a home page that extols the companies virtues and provides--in huge size--the logos of all the institutions using their technology. I had to scroll all the way to the very bottom to find the menu that should have been at the top--the pages that actually tell you about the company and the basis of this technology.

Then looking at "Our Story", I see that the entire focus of what they do is the ability to distinguish a great many more individual T-cell receptor identities than the standard technology--about 10 million as opposed to about 30,000. (The T-cell receptor is a multipartite creature with both fixed and variable components, with an incredible number of possible combinations.) T cells may be the most well-known term, but they aren't the whole story by a long shot when it comes to understanding and attempting to manipulate the immune response in a given situation. It is part of adaptive immunity. But first there is the innate immune system, which kicks in first, and rapidly, and stimulates the slow-to-going adaptive immunity only if it cannot do the job itself. Dendritic cells are the critical intermediary immune cells that initiate adaptive activation. Macrophages and Natural Killer cells, both lymphocytes, are also considered part of innate immunity. Innate immunity is complex and full of puzzles, and is ESSENTIAL for calling up a T cell response. A great deal of research focuses on multiple aspects of innate immunity and its interactions with adaptive immunity.

Then I looked at "Technology," and I was floored to see their description of the innate immune system, like a sleepy little hold-over from ancient times that deals only with microbes, and can't hold a candle to the T cell powerhouse.

Thumbs down.

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