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Without getting into too much detail, remember that in MFS if one of the spouses itemize deduction, the other MUST do it as well. Therefore, the one with the higher income may end up with almost nothing as standard deduction.
Also, you can only claim the medical expenses for the child if you use the child as your dependent. If you end up with no income (or negative after deductions), your refund will be only the amount that was paid in federal income taxes.
Normally MFS is not the most beneficial filing status, however each case is different. I would suggest that you try both status and use the most beneficial; and thta is perfectly legal.
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