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Author: VeeEnn Big gold star, 5000 posts Old School Fool Add to my Favorite Fools Ignore this person (you won't see their posts anymore) Number: of 40756  
Subject: Re: OMG!1!.....<i><b>they're</i&g Date: 10/2/2012 6:35 AM
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Yes, but within limits. The problem is prolonged T2D, without diet and exercise control, leads to pancreatic beta-cell apoptosis (death). Once that occurs, it is non-reversible and, basically, the same as T1D. When one gets to the stage of insulin-dependent T2D (beta-cell apoptosis), it's basically the same as T1D, with added metabolic dysfunction.

Darn tootin'

Here's a perfect case of you don't know what you don't know.....or more specifically, don't bother to think much about. I like to understand how stuff works (stuff I'm interested in, that is) but I have to say that I hadn't given T2D too much thought at cellular level on account of molecular biology is hard and a bit above my pay grade etc. etc. Anyhoo, dh sits on NIH grant committees a couple of times a year and a few years back he ended up reviewing a couple of applications based on the types of exercise interventions that were the most effective in metabolic syndrome, early T2D etc.

They weren't primarily ex. phys. based but I got wind of what he was reading because he kept asking me about things like VO2Max testing and lactate threshold (yeah, I know it's an old hat term but you can't expect physicians to know that) I strted looking at the references the would be authors were citing and, lo, found a whole other area I knew nothing about......the mitochondrial "perturbations" underlying T2D (evident, apparently, in young, lean, asymptomatic blood relatives of obese diabetics) Even had to have a tutorial on NMRS from the bro-in-law. Remember a while back I mentioned you shouldda got a gig in lipid metabolism......this is what I meant.

This is part of the little project I have going with my online trainer buddy.....not so much to spread the diet and exercise message to folk who already are symptomatic (they know already) but rather their young, asymptomatic relatives who're headed in the same direction if they don't get their act together ahead of time.

I sent the study link to her as "another puzzle piece" for her perusal and she was pretty interested also.
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