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Subject:  Re: Off of insulin! Date:  8/19/2003  6:45 PM
Author:  OleDocJ Number:  254 of 2885

This causes me some concern since my total cholesterol level is 110. What are some of the cholesterol metabolism disorders that I should be on the lookout for?

I can't answer the what to look out for question. But, like IP said, cholesterol plays a central role in lipid metabolism and tissue structure. Total serum cholesterol <130 mg/dL is considered "hypocholesterolemia." There are a number of inherited disorders of cholesterol and lipoprotein metabolism but these do not apply to you but do indicate the importance of this metabolism in normals as well. Severe hypocholesterolemia correlates with increased mortality during hospital care (trauma, surgery, severe infections, etc).

With a level of 110 for TC, I would be concerned that your HDL levels are probably too low (<35-40 mg/DL). I don't know your overall profile; you'll have to discuss it with your MD, but certainly lowering the Lipitor to 10 mg would appear to be reasonable. If your TG's are still too high on 20 mg, it might be that your low TC might be causing a longer postprandial metabolism of dietary fat (elevated VLDL).


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