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I tried lowest-dose Invokana some years ago. It's effectiveness was reduced even further (by 50%) due to another drug I took (info from the Invokana official tech info page about drug interactions), but it still worked effectively. I was also taking a statin, but it was generic Lipitor (atorvastatin calcium) and there was no apparent problem with that drug. When I told the doctor about the 50% reduction in effectiveness, the Invokana was stopped.
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