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In addition to the better known liver dammage, skeletal muscle depletion and kidney failure, one of their primary concerns is that statins deplete the body of coenzyme Q-10, a critical antioxidant for the heart, thereby seriously increasing the risk of oxidative damage to tissues body wide.

I've heard this argument but I haven't checked it out to see how valid it is. I take CoQ-10 supplements anyway.

Actually, CoQ-10 is a cofactor for the oxidation reactions of the oxidative phosphorylation pathway in mitochondria. The mitochondria of both heart muscle and skeletal muscle use the ox-phos to generate lots of energy for muscle work as they "burn" the pyruvate produced by glycolysis to lactic acid (Cori cycle).

Here's a nice little biochemistry site...

http://web.indstate.edu/thcme/mwking/


OleDoc


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