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incylong RE: "Here is a prediction for you, there will always be some small molecule and protein (antibody) drugs but in the future, I expect that antisense will be the primary mode of suppressing genes therapeutically and enhanced gene expression will be accomplished by targeted gene therapy that delivers the gene of interest and/or a transcription factor for the gene. Where antibodies and other proteins are needed, they will often be delivered as genes by viruses (or naked DNA)."

And here's a prediction for you: ten years from now there will only be one blockbuster antisense drug and one blockbuster gene therapy on the market. Everything else will be either a small molecule or protein (mostly the former).

The more things change, the more they stay the same.

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