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Is there any reason to believe that some SSRI derivative couldn't produce the same effects as the more traditional drugs, but acting on the basis of inhibition of reuptake of the various neurotransmitters, rather than direct stimulus? LLY certainly is positioned to know a lot about SSRI's.

It's a provocative approach, assuming all the receptors involved with ADD have been fully characterized.

It's unclear what the abuse potential of such a drug would have, and abandoning all reason, what the DEA / FDA would think, regardless of facts. If the same receptors end up being stomped on via inhibition of reuptake, versus stimulus, the net result would seem to me to be nearly the same.

However, the MAOI's (monoamine oxidase inhibitors), which act also by suppression rather than stimulation, have never been on the BNDD/DEA list. Of course, the MAOIs except for the selective Eldepryl are so dangerous if misused, that may be the reason; even Eldepryl can pose a risk of uncontrolled pressor amines if taken in excess of 10 mg/day along with the risk foods or beverages, or an OTC cold/allergy pill.

The first company that comes out with clinically proven, safe, effective ADD drug that isn't a Controlled Substance is going to be interesting to a lot of people.

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