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Mirati is showing some promise, though its via a few small trials in which they are mixing and matching a handful of different treatments. Hard to really know the signal vs noise. It's still a bit early for me based on them not really having Phase 2 trial data, but promising.

Preliminary efficacy data as of August 30, 2020 in patients with advanced NSCLC treated with adagrasib as a monotherapy at a 600 mg BID dose:

Patients had a median of two prior systemic treatments, including all patients receiving prior treatment with platinum-based chemotherapy regimens and 92% of patients receiving prior treatment with an anti-PD-1 /L1 inhibitor
Efficacy data from pooled Phase 1/1b cohort and Phase 2 registration-enabling cohort (n=51):
45% (23/51) confirmed objective response rate (ORR)
70% (16/23) of responders had a best tumor response greater than 40%
96% (49/51) disease control rate (DCR)
3.6 months median duration of follow-up
65% (33/51) of patients remain on treatment
83% (19/23) of responders have not progressed and remain on treatment
Efficacy data from the Phase 1/1b cohort (n=14):
43% (6/14) confirmed ORR
100% (14/14) DCR
8.2 months median duration of treatment
50% (7/14) of patients remain on treatment
83% (5/6) of responders remain in response and on treatment
4 of 6 responders have a duration of treatment for >11 months and all 4 patients remain on treatment

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