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. . . in a simple yeast cell:

The closest look ever at the cell's machines

http://www.embl.org/aboutus/news/press/2006/press22jan06.html

"To carry out their tasks, most proteins work in dynamic complexes that may contain dozens of molecules," says Giulio Superti-Furga, who launched the large-scale project at Cellzome four years ago. "If you think of the cell as a factory floor, up to now, we've known some of the components of a fraction of the machines. That has seriously limited what we know about how cells work. This study gives us a nearly complete parts list of all the machines, and it goes beyond that to tell us how they populate the cell and partition tasks among themselves."

And:

"This would be a logistical nightmare if the cell had to build every machine from scratch any time it needed to do something," says Anne-Claude Gavin, former Director of Molecular and Cell Biology at Cellzome and currently a team leader at EMBL. "We've discovered that the reality is different. Cells use a mixed strategy of prefabricating core elements of machines and then synthesizing additional, snap-on molecules that give each machine a precise function. That provides an economic way to diversify biological processes and also to control them."

Proteins working in dynamic complexes, prefab core elements with snap-on tools for specific jobs . . . AMAZING what evolution can do just inside a single cell.

Multiple parts, fitting together precisely to accomplish a function. Like clock-work. Amazing.

Bryan
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