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Oral Endothelin Receptor Antagonist Tracleer Meets Primary Endpoint In Pulmonary Arterial Hypertension Study

-- Actelion and Genentech announce positive results of Tracleer Phase III trial; Data will supplement US and European market authorization filing --


ALLSCHWIL, SWITZERLAND and SOUTH SAN FRANCISCO, CALIF., -- May 1, 2001 -- Actelion Ltd. (SWX New Market: ATLN) and Genentech, Inc. (NYSE: DNA) announced positive results today from a Phase III trial (BREATHE-1) of the first orally active endothelin receptor antagonist, Tracleerâ„¢ (bosentan) in pulmonary arterial hypertension (PAH). PAH is a potentially life-threatening chronic condition that that can severely compromise the function of the lungs and heart. In the BREATHE-1 trial, Tracleer demonstrated statistically significant improvements over placebo in the primary efficacy endpoint of the study, exercise capacity.

Rest of the article here:

http://www.gene.com/gene/news/2001/20010501-210144.html

Regards

CF
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